Precision Genomic Medicine

Recent advances in high-throughput genomics have enabled numerous efforts in Precision Medicine. Just a decade ago, sequencing a whole human genome was tremendously expensive and took years, but today, that process costs less than $1000 and is completed in hours, benefitting many patients.  Sequencing technology continues to improve, and the Institute for Precision Medicine remains active in its evolution within our healthcare ecosystem – not only in acquisition of hardware and construction of facilities, but in how researchers and physicians are able to access and utilize these resources. Precision genomics is being used in many clinical practices including preemptive and reactive pharmacogenomics, diagnosing newborn illness in the NICU using whole genome sequencing and sequencing tumors to direct targeted therapies.     

The increased use of genomics technologies has generated a massive amount of patient data, and that trend will only accelerate. While there can be no doubt about the value of such a rich and deep resource, exploring large datasets brings with it new and profound challenges. IPM continues to work with University of Pittsburgh and UPMC experts in bioinformatics, artificial intelligence, federated data systems, and machine learning to ensure that data streams are constructed in the most efficient way possible at the outset and are integrated with clinical data for efficient translation to clinical care.