Precision Medicine is a medical approach that proposes to prevent and treat disease based upon a person’s unique genetic makeup and their lifestyle habits. Precision medicine, the ability to accurately measure specific predictors of patient outcomes is implemented in personalized clinical care. Doctors have been performing precision medicine and personalized care for many years. For example, high blood pressure (hypertension) is commonly measured as a modifiable risk factor for vascular disease. However, advances in the basic knowledge of biology and disease, and advances in technologies now allow many more biomarkers to be measured to predict disease and target therapy. For example, in breast cancer the precision medicine involves the measurement of estrogen receptor as a biomarker for personalized use of anti-hormone therapy. Precision medicine incorporates the complexity of biology and disease though multi-scale analysis and systems biology. Such analysis often requires large scale data analytics and computational biology.